Vol. 130

Latest Volume
All Volumes
All Issues

Reconstruction of Microwave Absorption Properties in Heterogeneous Tissue for Microwave-Induced Thermo-Acoustic Tomography

By Jinguo Wang, Zhiqin Zhao, Jian Song, Xiaozhang Zhu, Zai-Ping Nie, and Qing Huo Liu
Progress In Electromagnetics Research, Vol. 130, 225-240, 2012


Aiming to efficiently overcome the acoustic refraction and accurately reconstruct the microwave absorption properties in heterogeneous tissue, an iterative reconstruction method is proposed for microwave-induced thermo-acoustic tomography (MITAT) system. Most current imaging methods in MITAT assume that the heterogeneous sound velocity (SV) distribution obeys a simple Gaussian distribution. In real problem, the biological tissue may have several different inclusions with different SV distribution. In this case, the acoustic refraction must be taken into account. The proposed iterative method is consisted of an iterative engine with time reversal mirror (TRM), fast marching method (FMM) and simultaneous algebraic reconstruction technique (SART). This method utilizes TRM, FMM and SART to estimate the SV distribution of tissue to solve the phase distortion problem caused by the acoustic refraction effect and needs little prior knowledge of the tissue. The proposed method has great advantages in both spatial resolution and contrast for imaging tumors in acoustically heterogeneous medium. Some numerical simulation results are given to demonstrate the excellent performance of the proposed method.


Jinguo Wang, Zhiqin Zhao, Jian Song, Xiaozhang Zhu, Zai-Ping Nie, and Qing Huo Liu, "Reconstruction of Microwave Absorption Properties in Heterogeneous Tissue for Microwave-Induced Thermo-Acoustic Tomography," Progress In Electromagnetics Research, Vol. 130, 225-240, 2012.


    1. Ku, G., B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, "Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging," Technol. Cancer Res. Treat., Vol. 4, No. 5, 1-7, 2005.

    2. Kruger, R. A., P. Liu, Y. R. Fang, and C. R. Appledorn, "Photoa-coustic ultrasound (PAUS) --- Reconstruction tomography," Med. Phys., Vol. 22, No. 10, 1605-1609, 1995.

    3. Ku, G. and L. V. Wang, "Scanning microwave-induced thermoacoustic tomography: Signal, resolution and contrast," Med. Phys., Vol. 28, No. 1, 4-10, 2001.

    4. Zeng, X. and G. Wang, "Numerical study of microwave-induced thermo-acoustic effect for early breast cancer detection," IEEE Antennas and Propagation Society International Symposium, 839-842, 2005.

    5. Xu, M. and L. V. Wang, "Pulsed-microwave-induced thermoacoustic tomography: Filtered backprojection in a circular measurement configuration," Med. Phys., Vol. 29, No. 8, 1661-1669, 2002.

    6. Hristova, Y., P. Kuchment, and L. Nguyen, "Reconstruction and time reversal in thermoacoustic tomography in acoustically homogeneous and inhomogeneous media," Inv. Probl., Vol. 24, No. 5, 055006, 2008.

    7. Hristova, Y., "Time reversal in thermoacoustic tomography --- An error estimate," Inv. Probl., Vol. 25, No. 5, 055008, 2009.

    8. Agranovsky, M. and P. Kuchment, "Uniqueness of reconstruction and an inversion procedure for thermoacoustic and photoacoustic tomography," Inv. Probl., Vol. 23, No. 5, 2089, 2007.

    9. Jin, X. and L. V. Wang, "Thermoacoustic tomography with correction for acoustic speed variations," Phys. Med. Biol., Vol. 51, 6437-6448, 2006.

    10. Jin, X., C. Li, and L. V. Wang, "Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography," Med. Phys., Vol. 35, No. 7, 3205-3214, 2008.

    11. Zhang, J. and M. A. Anastasio, "Reconstruction of speed-of-sound and electromagnetic absorption distributions in photoacoustic tomography ," Proc. SPIE, Vol. 6086, 339-345, 2006.

    12. Xie, Y., B. Guo, J. Li, G. Ku, and L. V. Wang, "Adaptive and robust methods of reconstruction (ARMOR) for thermoacoustic tomography," IEEE Trans. Biomed. Eng., Vol. 55, No. 12, 2741-2752, 2008.

    13. Cox, B. T. and B. E. Treeby, "Artifact trapping during time reversal photoacoustic imaging for acoustically heterogeneous media," IEEE Trans. Med. Imag., Vol. 29, No. 2, 387-396, 2010.

    14. Xu, Y. and L. V. Wang, "Effects of acoustic heterogeneity in breast thermoacoustic tomography," IEEE Trans. Ultrason., Ferroelect. Control., Vol. 50, No. 9, 1134-1146, 2003.

    15. Li, S., K. Mueller, M. Jackowski, D. Dione, and L. Staib, Fast marching method to correct for refraction in ultrasound computed tomography, IEEE International Symposium in Biomedical Imaging (ISBI), 896-899, 2006.

    16. Andersen, A. and A. Kak, "Simultaneous algebraic reconstruction technique (SART)," Ultrason. Imaging, Vol. 6, 81-94, 1984.

    17. Duric, N., P. Littrup, L. Poulo, A. Babkin, R. Pevzner, E. Holsapple, O. Rama, and C. Glide, "Detection of breast cancer with ultrasound tomography: First results with the computed ultrasound risk evaluation (CURE) prototype," Med. Phys., Vol. 34, No. 2, 773-785, 2007.

    18. Li, S., M. Jackowski, D. Dione, L. Staib, and K. Mueller, "Refraction corrected transmission ultrasound computed tomography for application in breast imaging," Med. Phys., Vol. 37, No. 5, 2233-2246, 2010.

    19. Duric, N., P. Littrup, A. Babkin, D. Chambers, and S. Azevedo, "Development of ultrasound tomography for breast imaging: Technical assessment," Med. Phys., Vol. 32, No. 5, 1375-1386, 2005.

    20. Quan, Y. and L. Huang, "Sound-speed tomography using first-arrival transmission ultrasound for a ring array," Proc. SPIE, Vol. 6513, 2007.

    21. Xu, Y. and L. V. Wang, "Time reversal and its application to tomography with diffracting sources," Phys. Rev. Lett., Vol. 92, No. 3, 1-4, 2004.

    22. Fink, M., "Time reversal of ultrasonic fields I. Basic principles," IEEE Trans. Ferroelectrics, Frequency Control., Vol. 39, No. 5, 555-567, 1992.

    23. Fink, M. and C. Prada, "Acoustic time reversal mirror," Inv. Probl., Vol. 17, No. 1, 1-38, 2001.

    24. Chen, G. P., Z. Q. Zhao, Z. P. Nie, and Q. H. Liu, "A computational study of time reversal mirror technique for microwave-induced thermo-acoustic tomography," Journal of Electromagnetic Waves and Applications, Vol. 22, No. 12, 2191-2204, 2008.

    25. Chen, G. P., W. B. Yu, Z. Q. Zhao, Z. P. Nie, and Q. H. Liu, "The prototype of microwave-induced thermo-acoustic tomography imaging by time reversal mirror," Journal of Electromagnetic Waves and Applications, Vol. 22, No. 11, 1565-1574, 2008.

    26. Zhang, H., C. Thurber, and C. Rowe, "Automatic P-wave arrival detection and picking with multiscale wavelet analysis for single-component recordings," Bull. Seism. Soc. Am., Vol. 93, No. 5, 1904-1912, 2003.

    27. Ramananantoandro, R. and N. Bernitsas, "A computer algorithm for automatic picking of refraction first-arrival-time," Geoexploration, Vol. 24, No. 2, 147-151, 1987.

    28. Capozzoli, A., C. Curcio, and A. Liseno, "GPU-based omega-k tomographic processing by 1D non-uniform FFTs," Progress In Electromagnetics Research M, Vol. 23, 279-298, 2012.

    29. Jiang, M. and G. Wang, "Convergence of the simultaneous algebraic reconstruction technique (SART)," IEEE Trans. Imag. Proc., Vol. 12, No. 8, 2003.

    30. Guo, B., Y. Wang, J. Li, P. Stoica, and R. Wu, "Microwave imaging via adaptive beamforming methods for breast cancer detection," Journal of Electromagnetic Waves and Applications, Vol. 20, No. 1, 53-63, 2006.

    31. Mast, T. D., "Empirical relationships between acoustic parameters in human soft tissue," Acoust. Res. Lett., Vol. 1, No. 2, 37-42, 2000.

    32. Cox, B. T., S. Kara, S. R. Arridge, and P. C. Beard, "k-space propagation models for acoustic heterogeneous media: Application to biomedical photoacoustic ," J. Acoust. Soc. Am., Vol. 121, No. 6, 3453-3464, 2007.

    33. Treeby, B. E. and B. T. Cox, "k-wave: A MATLAB toolbox for the simulation and reconstruction of photoacoustic wave-fields," J. Biomed. Opt., Vol. 15, No. 2, 021314, 2010.

    34. Li, C., L. Huang, N. Duric, H. Zhang, and C. Rowe, "An improved automatic time-of-flight picker for medical ultrasound tomography," Ultrasonic, Vol. 49, No. 1, 61-72, 2009.